Objective To study the gene polymorphism at positions C-2123G,G-1969A,T-1817C and Thr715Pro in Chinese Han population of Hubei Province and compare the distributions of genotype and allele frequencies with other races.Methods The frequencies of promoter region of P-selectin gene C-2123G,G-1969A,T-1817C and Thr715Pro genotype and allele were detected by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) in 200 normal individuals of Chinese Han population in Hubei Province,China.Results In Chinese Han population the most frequent genotype of P-selectin at C-2123G was GG type,the second was CG type and the least was CC type.At G-1969A position GG type was the most frequent genotype,but no AA type was found.At T-1817C position TT type was the most frequent genotype of P-selectin,while CC type was the least.No difference of P-selectin polymorphism at the above 3 positions was found between male and female(P>0.05).Compared with the data of France,Germany and the UK,the distributions of genotypes at the above 3 positions of P-selectin were significantly different among various races(P<0.01 or P<0.001).No polymorphism of Thr715Pro was found in this study.Conclusion In Chinese Han population the gene polymorphisms existed at the positions C-2123G,G-1969A and T-1817C of promoter region of P-selectin,and their distributions were significantly different from other races.There was no gene polymorphism at the position Thr715Pro in Chinese Han population.