Abstract: Objective：To evaluate the correlation between hyperuricemia and metabolic syndrome in medical staff and the risk factors resulted in hyperuricemia, and provide the evidences for reducing the risk suffering from hyperuricemia by improving the lifestyle. Methods：A total of 2 763 medical staff who received the physical examination in the same hospital in Beijing were enrolled in this study. Based on the levels of serum uric acid of participants, the reference interval of serum uric acid in healthy subjects was set up. The risk factors resulted in hyperuricemia and the relationship between hyperuricemia and metabolic syndrome were analyzed by the univariate and multivariate logistic regression analysis. Results：The reference intervals of serum uric acid for males and females younger than 50 years of age (including 50 years old) were 244 to 496 μmol/L and 175 to 398 μmol/L respectively, and the females older than 50 years were 183 to 415 μmol/L. The multivariate logistic regression analysis indicated that overweight (OR=2.312, 95% CI 1.840 to 2.905), high blood pressure (OR=1.902, 95% CI 1.470 to 2.463), elevated triglycedies (OR=1.765, 95% CI 1.372 to 2.272) and metabolic syndrome (OR=3.906, 95% CI 3.052 to 5.001) were all the independent risk factors resulted in hyperuricemia. The serum uric acid levels rose with increased abnormal criteria for diagnosis of metabolic syndrome (P<0.05), and the risk suffering from hyperuricemia increased by 1.723 times (95% CI 1.567 to 1.896) for each additive abnormal criteria. Conclusion：The reference interval of serum uric acid established in this investigation was higher than that in the previous reports. MS may be the independent risk factors resulted in hyperuricemia.