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北京协和医院2012—2017年体检人群高尿酸血症患病率变化及与血糖、血脂相关性的调查
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中国医学科学院北京协和医院检验科,中国医学科学院北京协和医院检验科,中国医学科学院北京协和医院检验科,中国医学科学院北京协和医院检验科,中国医学科学院北京协和医院检验科,中国医学科学院北京协和医院检验科,中国医学科学院北京协和医院检验科,中国医学科学院北京协和医院检验科,中国医学科学院北京协和医院检验科,中国医学科学院北京协和医院检验科,中国医学科学院北京协和医院检验科,中国医学科学院北京协和医院检验科

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国家自然科学基金青年项目（81702060）；首发卫生发展科研专题项目（首发2016-2-4017）；国家临床重点专科建设项目（2011AA02A111）。


Investigate the prevalence of hyperuricemia in Peking Union Medical College Hospital from 2012 to 2017
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Department of Laboratory Medicine, Peking Union Medical College Hospital, Chinese Academic Medical Science and Peking Union Medical College,Department of Laboratory Medicine, Peking Union Medical College Hospital, Chinese Academic Medical Science and Peking Union Medical College,Department of Laboratory Medicine, Peking Union Medical College Hospital, Chinese Academic Medical Science and Peking Union Medical College,Department of Laboratory Medicine, Peking Union Medical College Hospital, Chinese Academic Medical Science and Peking Union Medical College,Department of Laboratory Medicine, Peking Union Medical College Hospital, Chinese Academic Medical Science and Peking Union Medical College,Department of Laboratory Medicine, Peking Union Medical College Hospital, Chinese Academic Medical Science and Peking Union Medical College,Department of Laboratory Medicine, Peking Union Medical College Hospital, Chinese Academic Medical Science and Peking Union Medical College,Department of Laboratory Medicine, Peking Union Medical College Hospital, Chinese Academic Medical Science and Peking Union Medical College,Department of Laboratory Medicine, Peking Union Medical College Hospital, Chinese Academic Medical Science and Peking Union Medical College,Department of Laboratory Medicine, Peking Union Medical College Hospital, Chinese Academic Medical Science and Peking Union Medical College,Department of Laboratory Medicine, Peking Union Medical College Hospital, Chinese Academic Medical Science and Peking Union Medical College,Department of Laboratory Medicine, Peking Union Medical College Hospital, Chinese Academic Medical Science and Peking Union Medical College

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    摘要:

    摘要：目的：调查北京协和医院2012—2017年体检人群高尿酸血症（HUA）患病率变化及与血糖、血脂的相关性。 方法：采用观察性研究方法。调取北京协和医院2012年1月至2017年12月399 089例（男206 881例，女192 208例）体检者尿酸（UA）、空腹血糖（FBG）、总胆固醇（TC）、三酰甘油（TG）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、肌酐（Cr）、尿素（Urea）检测结果并统计分析。 结果：HUA总患病率为17.4%，男性HUA患病率高于女性（25.6% vs 8.5%，χ2=20 234.850，P＜0.01）。2012—2017年男性HUA患病率分别为26.5%、24.7%、28.6%、23.9%、24.8%、24.5%，女性HUA患病率分别为13.8%、6.3%、7.9%、6.1%、6.2%、6.8%。2012—2017年均表现为18~64岁年龄组男性HUA患病率高于女性（P均＜0.05），≥65岁年龄组男性HUA患病率与女性相近，其中2013、2015、2016、2017年≥65岁年龄组男、女性HUA患病率差异无统计学意义（χ2分别为1.792、0.017、1.440、0.205，P均＞0.05）。男、女性HUA组高血脂比例高于男、女性non-HUA组（P均＜0.01）；男性non-HUA组高血糖比例高于男性HUA组，但女性non-HUA组高血糖比例低于HUA组（P均＜0.01）。高TC、TG、FBG是HUA的危险因素，随着浓度升高，OR值升高。 结论：北京协和医院体检人群近6年来男性HUA患病率整体处于较高水平，女性HUA患病率呈下降趋势，且相对稳定。高血脂、高血糖是HUA的危险因素。

    Abstract:

    Objective To investigate the prevalence of hyperuricemia (HUA) under healthy check-ups of Peking Union Medical College Hospital (PUMCH) from 2012 to 2017. Methods Observation study. The results of the general biochemical tests of 399,089 cases (206,881 males and 192 208 females) of PUMCH from January 2012 to December 2017 were collected and statistically analyzed. Results From January 2012 to December 2017，the total prevalence of HUA in PUMCH was 17.4%. The prevalence of HUA in males was higher than that in females （25.6% vs 8.5%,P <0.01）. During the study period, the prevalence of HUA in the 18-24-year-old group was relatively stable, and the prevalence of HUA in the 25-34-year-old, 35-44-year-old, and 45-54-year-old groups showed an increasing trend, 55-64 and ≥65 years old. The prevalence of HUA in the group showed a gradual decrease. High levels of TC, TG and FBG were risk factors for HUA，The ORs were 2.20 （95% CI: 2.18-2.23）， 4.04 （95% CI: 3.78-4.31） and 2.45 （95% CI: 0.74-8.14） with increasing concentrations, respectively. Conclusions In recent years, the prevalence of HUA in PUMCH has shown a downward trend, but the overall level is still at a relatively high level.

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王丹晨,尹逸丛,禹松林,国秀芝,侯立安,李洪雷,由婷婷,程倩,写稍微,程歆琦,夏良裕,邱玲.北京协和医院2012—2017年体检人群高尿酸血症患病率变化及与血糖、血脂相关性的调查[J].临床检验杂志,2018,(6):462-466

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  • 收稿日期:2018-02-02
  • 最后修改日期:2018-06-28
  • 录用日期:2018-06-11
  • 在线发布日期: 2018-07-05
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