Objective To investigate the clinical epidemiological characteristics of OXA-232-producing Klebsiella pneumoniae (OXA-232Kp). Methods The clinical isolates of carbapenem-resistant Klebsiella pneumoniae (CRKP) from 5 hospitals in Jiangsu province during September 2018 and September 2019 were collected, and their drug susceptibility were analyzed by the microbroth dilution method and Phoenix-M50 automatic microbiological system. The blaOXA-232 gene was detected by PCR and sequencing. The homology of the strains was analyzed by the pulsed field gel electrophoresis (PFGE). The surrounding environment of the plasmid carrying blaOXA-232 gene was analyzed by the plasmid sequencing. Results Three strains of OXA-232Kp ST15 were screened. PFGE analysis showed that they were clonal transmission, and carried the 6 141 bp ColKP3 plasmid, which was highly homologous with the plasmid carrying the blaOXA-232 gene found in eastern China. Conclusion This is the first time to investigate the epidemiological characteristics of OXA-232Kp ST15 in Jiangsu province. The high homology of the plasmid carrying blaOXA-232 indicates that the 6 141 bp ColE type plasmid plays an important role in the prevalence of OXA-232 in Jiangsu region.