Abstract:Objective 'To analyze the influence of HIN dng resistance genotypes on the outcomes of antiretroviral treatment in AIDSpatients.Methods A total of 499 AIDS patients were included as the research subijects. Drug resistance genotypes were detected andcompared with the database. Sinmultaneously ，viral load and the absolute counts of CD4* lymphocyte were measured.'The genotypes ofdrnug resistance and effects of clinical treatment were analzed.Results Among the 499 cases studiel , 409 samples were success$iullyamplified and sequenced, and 181 cases occurred drug resistance.The patients wih drug resistance were significantly older than thosewithout drug resistance，and their CD4* absolute cell counts were significantly lower.Nucleoside reverse transcriptase inhitors (NB-II) and non-nucleoside reverse transcriplase inhibitors (NNRTls) were more likely to develop high-level drug resistance compared toprotease inhibitors ( PI ).Additionally , drug-resistant patients had higher viral loals. Conclusion The overall incidence of dnug resist-ance in AlDS patients in Nanjing area is relatively low， but the proportion of multidrug-resistant and highly resistant patients amongthose with drug resistance is relatively high. During diagnosis and reatment, clinical indicators should be monitorel , and antiretroviraltreatment plans should be adjusted in a timely manner with preference given to the antiretrovinal drugs with high resistance baiers.