Abstract : Objective To construct a model for predicting the survival time of colorectal cancer(CRC) patients based on the preopera-tive carcinoembryonic antigen(CEA ) and carbohydrate antigen 19-9(CA19-9)levels.Methods 313 patients with CRC from JiangmenCentral Hospital were collcted and their preoperative serum CEA and CA19-9 levels were dected using a Beckman Access chemilu-minescence immunoassay analyzer.TheX'test was used to evaluate the relationships between CEA and cinical pathological factors andhbetween CA19-9 and clinical pathological factors, and the Kaplan-Meier survival analysis and Cox multivariate analysis were used to as-sess the survival and prognosis of patients , respectively.Results CEA and CA19-9 levels were correlaterd with 'TNM staging, clinicalstages l,Ⅱ Ⅲ , and N , progression , recurrence，vascular invasion , and metastatic sites of CRC( P<0.05 ). The overall survival time(0S ) of patients with elevated CEA was shorter than that of patients with normal CEA,with a total of 76.85 months，while the 0S ofpatients with normal CEA was 110.83 months(P=0.000). The same trend was olserved i patients with elevated CA19-9( P=0.000).Cox mulivariale analysis found that CEA and CA19-9 were independent predictors of survival in CRC patients( HR=2.190 and 2.874,95%CI=1.486-3.225 and 1.947-4.242，respectively;P<0.05). A model formula combining CEA and CA19-9 was constructed, assig-ning a score of 0 for normal CEA, 1 for elevated CEA, and 0 for normal CA19-9, 1 for elevated CA19-9.The CC value was set to equalCEA score+CA19-9 score. It was found that the patients with the highest CC value had the shortest OS, while the patients with the low-est CC value had the longest OS( P<0.05). Concusion The established CEA and CA19-9 model formula can effectively distinguishthe prognosis of CRC patients.