Abstract: Objective To analyze the characteristics and influencing factors of antibody levels in patients with mild SARS-Cov-2 infection after rehabilitation, and provide evidence for the prevention and control of SA RS-Cov-2 infection. Methods The remaining serum samples after physical ex amination or in-patient detection in Shanghai Tenth People's Hospital from January 5 to May 22, 2023 were randomly selected. The levels of IgG, IgM and neutralizing antibody against SARS-Cov-2 were detected by the magnetic particle-based chemiluminescence immunoassay. Relevant informations were collected and statistical analysis was performed using SPSS 26.0 sofware.Results A total of 210 serum samples of recovered patients with mild SARS-Cov-2 infection were included, with a median age of 41 (33, 59) years and a median infection time of 54( 29, 64) days. Among them, there were 103 males( 49% ) and 107 females(51%).80( 38. 1% ) had no underlying diseases and 130( 61.9% ) had undedying diseases. Antibody levels were influenced by multiple factors，and gender , underlying diseases, and vaccination doses had important impacts on antibody levels. The levels of IgG and neutralizing antibodies in female patients with mild SARS-Cov-2 infection were higher than those in males, while the IgM levels were lower than those in males. The levels of IgG and neutralizing antibodies in female patients with underlying diseases were lower than those without underlying ilnesses, while the IgM levels were higher than those without underlying ilnesses. The patients vaccinated the vaccines against SARS-Cov-2 had higher levels of IgG and neutralizing antibodies than those without vaccination, while those received the booster vaccination had higher levels of IgG and neutralizing antibodies. There was no significant correlation between antibody levels and infection time, age, and body mass index( BMI). Conclusion Female patients with mild SARS-Cov-2 infection may have higher immune protection levels and a lower risk of infection. The patients with underlying diseases may have lower immune protection levels and a higher risk of infection. Boosting vaccinations against SARS-Cov-2 can produce higher levels of antibodies.