Abstract: Ohjective To evaluate the clinical application value of the 5 estimated glomerular filtration ate( eGFR) formulas， inclti-ding MDRD,MDRD Chinese formula [ MDRDn.]，CKD-EPI,，CKD-EPL. and CKD-EPI ..y.c ， in assessing glomerular filtrationfunction and diagnosing chronic kidney dlisease (CKD) , and deternine the most stuitable fomula for the local region . Methods A to-tal of 2 610 outpatients and impatients from The First Afliated Hospital of Ningbo University were erolled as the stuly subjects. Serumcreatinine (Cr) and CysC levels were measured , and eCFR was estimated using the 5 formulas. The differences of eCFR values calct-lated by different formulas were compared. ln 412 inpatients ，the correlations between endlogenous creatinine clearance rate (eCr) andthe 5 eCFR results were analyzedl, and ROC curves were plotted to compare the diagnostic efficacy of the five eCFR values for CKD.The reference interval for eCFR was established using data from 239 healthy individuals.Results All the eCFR values calculated bythe 5 fomulas showed skewed distributions and differences of most pairwise compaisons were statistically significant. All the 5 eCFRvalues were significantly positively correlatedl with ecCr. The CKD-EPLC.,yc showed the highest comrelation coeficient ( r=0.903 ) . Theareas under the ROC curves for diagnosing CKD using the 5 eCFR formulas were 0.968,0.969,0.970,0.967 and 0.976，respectively.CKD-EPIC.c showed the best dliagnostic peformance ( ensitivity of 97.3% , specificity of 89.8 % ).The lower limits of the 95% confi-dence interval for healthy individuals were 76,87, 82, 99, andl 93 mL/min/1.73m' for the different formulas respectively. ConclusionAmong the five eCFR formulas，CKD-EPI..c with a reference inmterval lower limit of 93 ml/min/1.73m’was demonstrates as thebest diagnostic efficiency for assessing glomerular filtration function and diagnosing CKD, and is woth promoting and applying in Ning:bo region.