Abstract : Objective To estaHlish and optimize an automatic review system for eight report items of infectious disease in clinical lalwo-ratory. Methods Acorling to AUTO-15 issued by the Clinical and Laboratory Standands Institute ( CLSI) and WS/T 616—2018 is-sued by the Naional Health Commission of China , an automatic review nule system for eight test results of infectious disease was estab-lished based on mideware ( inmfinity) and laboratory information management system ( LIS). The automatic review and judgment forthe eight test results of infectious disease were carried out by using six rules : quality control , specimen status，instrument alarm , grayarea range, comventional mode， and historical data comparison ( Delia check ) . The effectiveness of the automatic review system wasverified by comparing the manual results with the automatic reviews, and the test system was further optimizedl for validating to achievethe automatic review for the eight test items.Results An automatic review rule system consisting of six function parts ( quality control,specimen stats ， instrtument alarm ,gray area range , conventional mode, and historical data comparison) was established. The sensitiv-ity and specificity of the automatic review rule system were 87% and 95%o , respectively , and the posive and negative predictive valueswere 88%e and 95% , respectively.After the manual results was adjusted with the established automatic review rules system , the approv-al rate of the eight report items of infectious disease increased from 39% to 85% in 2022 , the turnaround time (TAT) time was short-ened from 209 (52,215) min to 141 (83, 149) min, and the number of reviewers was reduced from 2 to 1.'Tlhe error rate of abnomaltest reports of positive results, including hepatitis B five indexes , HIV, and TP issued by the instruments was reduced to 0.04%.Con-clusion The automaic review system for eight repot items of infectious disease could greatly reduce the workloadl of reviewers , shor.en TAT，and decrease the risk of reporting errors.