Abstract: Objective To construct a Nomogram model combined with serum interleukin-6（IL-6), prostaglandin E2（PGE2) and tumor necrosis factor-α (TNF-a) to predict the risk of postoperative recurrence of bladder cancer. MethodsA total of 24O patients with bladdercancer underwent surgeryin the First People's Hospital of Linping District fromJanuary2019 toJanuary2023were selected. The patients with recurrence were included in the recurrence group and those without recurrence were included in the non-recurrence group after 12 to 6O months of follow-up. The levels of serum IL-6, PGE2 and TNF-a before surgery between the two groups were compared. The influencing factors of postoperative recurrence were evaluated by the multivariate stepwise Logistic regression analysis. A Nomogram model was constructed and its predictive efficacy was verified. ResultsThe levels of preoperative serum IL-6, PGE2, and TNF-α in the recurrence group were significantly higher than those in the non-recurrence group （P