Abstract:ObjectiveTo investigate the distribution of Streptococcus，sensitivity to commonly used antibiotics,and prognosis of the patients with bloodstream infections,and provide evidence for early diagnosis and selection of antibiotics. MethodsThe Streptococci i-solated from the blood samples of the First Affiliated Hospital of Nanjing Medical University from 2017 to 2022 were collected and di- vided into α- and β-hemolytic Streptococi according to the type of hemolysis. Their sensitivity to commonly used antibiotics was analyzed.Thediffrencesinclinicaldataandprognosisbetweenthetwogroupswerealocompared.ResultsAtotalof314strainsof Streptococcus were isolated from 305 patients,including 270 strains of a-hemolytic Streptococcus and 44 β-hemolytic Streptococcus. The results of the drug sensitivity test showed that the proportion of Streptococcus strains with a diameter of 17-19 mm in the inhibition zone of vancomycin increased year by year. The positive alarm time of blood culture for β-hemolytic Streptococcus was significantly shorter than that for a-hemolytic Streptococcus (P