Abstract: Ohjective To investigate the bloodl lipid levels in the population undergoing physical check-up population in Hangzhou dis-trict using the laboratory Big Data for providing references in disease prevention.MethodsThe test resuls of blood lipid levels of theindividuals undergoing health check-up at a certain hospital from Jamuary 2022 to October 2023 were collected,excluding the abnomalpositive resultss. SPSS 25.0 software was used to calculate the median(M) , 25th percentile(P. ) andl 75 Percentile( P.; ) grouped bygender and age in 10-year intervals. TMC was used to calculate 2.5th peroentile (P.s. ) and 97.5th percentile(P ns ) ， and CAMLSSwas used to draw the age-continous percentile charts.Results Gender differences in blood lipid levels were observed.T'he levels oftotal cholesterol (TC) , triglycerides (TC) , and low-density lipprotein cholesterol (LDL-C) in males were higher than those of fe-males in the age of 19 to 49 groups.However ,the levels of'TC and LDL-C in females were higher than those of males in the age of 50to 90 groups.TG levels in females were higher than those of males in the age of 60 to 90 groups.High-density lipoprotein cholesterol(HDL-C) levels in females were higher than those in males.TG level in males at ages of 40 to 49 reached peak ，while females reachedthe peak of TG level at ages of 70 to 79.The LIDL-C level in males at ages 40 to 49 reached the peak, while females reached the peakof LDL-C level at ages 60 to 69.Blood lipid levels were associated with age. The levels of TC，TC in female and LDL-C in femaleshowed particularly significant changes, firt increasing and then decreasing with age.Concusion Blood lipid levels are closely related to gender and age.Personalized lipid management should be conducted,considering the factors of gender and age.